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The authors used 25 healthy, occasional smokers in their study and found that regardless of nicotine, the presence of PG/VG in the e-vapor led to the observed results and pathology [65]

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1 , 5 Further in vitro studies have demonstrated the ability of ENDS e-liquids to induce changes contributing to the development of tumorigenesis in normal epithelial cells and promote aggressive phenotypes in pre-existing malignant cells