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For example, research published in Nature Medicine demonstrated that nicotine stimulates the vagus nerve, and, by extension, nicotinic receptors, reducing inflammatory cytokine production in models of sepsis

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Thus, the levels of the pro-inflammatory cytokines TNF, IL-1 , IL-6, IL-12, and IL-13 were elevated, whereas the levels of the anti-inflammatory cytokine IL-10 were reduced, in the lungs of exposed mice [115, 116]

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