Assuming 40 mL per puff and 15 puffs per e-cigarette unit (according to several manufacturers) [4], each e-cigarette unit would generate approximately 1.89 g of acrolein, which is less than the levels of acrolein emitted by a conventional tobacco cigarette (18.398.2 g) [51]
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Because of the adverse side effects associated with high doses of nicotinic acid (see Safety), nicotinic acid has most often been used in combination with other lipid-lowering medications at slightly lower doses (17)
