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The questionnaire was designed based on the standardized recommendations for smoking surveys from the WHO 21 , and tailored to meet the specific objectives of this study

Surgeon Generals Report, How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking - Attributable Disease , identifies inflammation and oxidative stress, among others, as key mechanisms underlying all major smoking-related diseases [3]

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It remains to be investigated if chemical composition of the two ECIG-flavors changes with wattage of ECIG device

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