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The team also contends that the complex shapes of the fossils suggest cell signaling and coordinated growth

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Commenters suggested that CMS consider innovative applications of statistical methodologies for the design and analysis of small sample data including: (1) Research designs and analytic methods that can maximize statistical power for analyses of interventions conducted with small, culturally distinct samplesincluding dynamic wait list research designs, Bayesian approaches, matching, imputation, or increasing look back periods, (2) strategies for reducing error and bias in measures applied in studies with culturally distinct samples such as the Rasch Measurement Model, and (3) use of qualitative methods and mixed methods combining qualitative and quantitative data

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