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For epigenetic drivers, the model predicted chromatin accessibility changes (Y) from the cell type-specific TF-regulatory element cis-regulation (A)

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Since concentrated cinnamon has a higher absorbance reading (i.e., is darker) than the other flavorings (see Table 1), addition of 25% concentrated cinnamon flavor to the E-liquid inherently increases the initial absorbance readings of the growth media, thus giving the appearance of a reverse dose effect