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A systematic review found that the reported prevalence of constipation was 2.626.9% 21

These animals, or the diseases they may carry, can harm local ecosystems when they enter the water supply

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Because the association between CUD and oral cancer remained even after controlling for smoking status, and because CUD was associated with greater oral cancer risk even when the analysis was restricted to smokers, the researchers hypothesize that there may be other factors underlying this risk in addition to smoke inhalation

All of these were conducted in Australia, where standardised packaging was introduced at the end of 2012