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In one characteristic study, published in 2022 in the American Journal of Gastroenterology , researchers compared admissions for CHS at a large Massachusetts hospital between 2012 and 2020, noting a significant uptick after cannabis was legalized in the state in late 2016

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As part of the drug review and approval process for the prescription drug containing CBD, it was determined that the risks are outweighed by the benefits of the approved drug for the particular population for which it was intended