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Recovering nicotines reputation would also provide a clear commercial benefit to tobacco companies, many of which are betting on smoke-free products as their future given global declines in smoking rates

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Of these deaths, 41,900 (95% CI, 28,40055,400) occurred in North America, including 33,000 (95% CI, 22,50043,500) in the USA and 8,300 (95% CI, 5,80010,800) in Canada (accounting for about 17% and 39% of total PM 2.5 attributable deaths or 1.2% and 2.9% of total all-cause deaths in those countries in 2023, respectively)