cigarettes invented date Safer" Cigarettes: A History | NOVA History of the emergence and

Additionally, tobacco exposure downregulates p53, a critical tumor suppressor gene, facilitating genomic instability and malignant transformation [34]

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Subsequent similar research found the same thing, but one important thing to note about these kinds of studies is that they cant show causation there was no reason to assume that the smokers werent getting lung cancer more often due to a simple coincidence, or some other unknown factor

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