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However, it is now crystal clear that it is the inhaled deadly smoke from cigarettes/combustibles that stands alone by orders of magnitude as a pinnacle of deadliness that greatly exceeds the disease and disability costs of a large number of consumer products added together as well as NRT, ANDS and all forms of non-combusted tobacco [36, 37]

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Targeting glycolytic enzymes has been shown to improve therapeutic response to anticancer agents [33], revealing the critical role of glycolysis in tumor progression and therapeutic resistance