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If you want a research-based summary comparing outcomes across nicotine replacement therapy, bupropion SR, and varenicline (including combination approaches), review the USPSTF tobacco cessation recommendation

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Nicotine may not be a good fit if it causes palpitations, anxiety, irritability, insomnia, headaches, nausea, dizziness, blood pressure changes, cravings, emotional crashes, increased histamine symptoms, or a need to keep using it to feel normal

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At the federal level, CBD derived from hemp with THC concentrations of less than 0.3 percent is legal, and some states have acted to legalize it in their jurisdictions