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The use of alcohol and nicotine was relatively low in the current sample

To address this gap in the literature, the present study was developed to analyze the characteristics of EVs released by BC cells exposed to cigarette smoke extract (CSE) or different E-liquids, with a specific focus on the ability of these EVs to promote the malignant transformation of recipient urothelial cells consistent with a potential field cancerization effect

These include, but are not limited to, the following: Expected EtO concentration level, which can be influenced by proximity to sources sampling locations atmospheric and meteorological conditions landscape and topography Proximity to known source in-stack sampling at the source near-source fugitive emissions near source / fence line background (see Section 1.1.2) community Analytical performance method detection limit or sensitivity repeatability robustness accuracy and precision (Figure 18) selectivity analytical background Potential sampling and measurement challenges moisture (in-stack sampling) humidity (canister sampling) co-eluting compounds (compounds that cannot be resolved from one another in EtO analysis and quantification) canister bias or formation of EtO in certain sampling canisters (see Section 6.5.1 for more information) Expected data use (see Section 6.6) user experience and expertise level of quality assurance / quality control required Other logistical concerns available power available climate-controlled facilities security and access facility operations (if applicable) environmental conditions (e.g., weather) The details discussed above are examples of items that should be considered as the sampling program for EtO is developed